Latest news and research on all cancers and treatments, updated several times a week, plus 10,000-item data base of these
Immunotherapy is a type of therapy that uses the body's own immune system to help fight cancer. Immunotherapy may help the body's immune system ...
Tumor-specific mutations are ideal targets for cancer immunotherapies as these mutations are not expressed in healthy tissues and can be potentially ...
It is also not known whether a safe and effective new immunotherapy treatment for cancer could be developed on the back of these results.
Prostate cancers also fail to respond to a promising new type of immunotherapy drugs, called checkpoint inhibitors, which disable cancer cells' ...
They bind to proteins from the foreign tissue and, through signaling cells, alert T cells, the immune system's SWAT team. When T cells encounter the ...
A new therapy that involves freeing up and boosting the immune system can wipe out advanced prostate cancer, early research has shown.
Novel combination therapy shows promise in mouse models of advanced prostate cancer - News-Medical.net
Combined chemotherapy and immunotherapy shows promise for advanced prostate cancers - Medical Xpress
"When the immune system is functioning, treatment options are more ... the immune system's ability to mount an effective defense and allowing cancer ...
New research suggests that patients recovering from bowel cancer surgery may be at a higher risk of relapse if their blood shows an immune ...
Cancer patients could be treated with laboratory-engineered antibodies that train the body's immune system to obliterate tumours, research suggests.
(Reuters) - Amgen Inc's skin cancer immunotherapy showed enough ... cancer cells when injected into tumors and also primes the immune system to ...
Head and neck cancer is the sixth leading cancer in the world and makes up 3 ... Head and neck cancer affects men two times more often than women. ... suppressed immune system, some environmental factors and certain diets ...
Feature: My Mighty Mouse
Personal drug regimens based on xenograft mice harboring a single patient’s tumor still need to prove their true utility in medicine.
Feature: Resisting Cancer
If one out of three people develops cancer, that means two others don’t. Understanding why could lead to insights relevant to prevention and treatment.
... week in Genome Medicine suggests that aristolochic acid, a compound present in herbal remedies, may contribute to bladder cancer development.
“People who live in sunny countries near the equator have only one-sixth of the age-adjusted incidence rate of pancreatic cancer as those who live far ...
Pancreatic cancer risk linked to weak sunlight - Medical Xpress
Oncolytics Biotech® (TSX: ONC, Stock Forum) pushed the commercialization process forward for its lead product candidate when the company ...
MM-302 Shows Promise in Heavily Pretreated HER2-Positive Breast Cancer
MM-302 showed encouraging efficacy results and a manageable safety profile in heavily pretreated HER2-positive metastatic breast cancer patients.
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MM-302 showed encouraging efficacy results and a manageable safety profile in heavily pretreated HER2-positive metastatic breast cancer patients.
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Complications of Bone Marrow Transplant in CLL Patients
This session at ONS reviewed treatment options for CLL and the issues associated with bone marrow transplantation in eligible patients.
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This session at ONS reviewed treatment options for CLL and the issues associated with bone marrow transplantation in eligible patients.
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Practical Management of Adverse Events Associated With Afatinib
In this video from the 2015 ONS meeting, Dr. Sipples talks about effective management of side effects for patients taking afatinib, an oral, targeted agent for lung cancer.
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In this video from the 2015 ONS meeting, Dr. Sipples talks about effective management of side effects for patients taking afatinib, an oral, targeted agent for lung cancer.
Read More »
Science Daily Cancer News
Pancreatic cancer rates are highest in countries with the least amount of sunlight, researchers report. Low sunlight levels in those countries, they say, were due to a combination of heavy cloud cover and high latitude.
A new targeted therapy drug against EGFR-mutation driven lung tumors that have become resistant to current therapies shows activity against the most common resistance mutation, significantly improving outcomes for patients.
For the first time, researchers have shown that a gene previously implicated in blood vessel formation during embryonic development and tumor growth also induces immune suppression during tumor development. This finding opens the door for new therapeutic approaches and vaccine development in treating patients with melanoma and other advanced-staged cancers.
Blocking or removing immune-suppressing cells allows a special type of chemotherapy — and the immune cells it activates — to destroy prostate tumors, researchers report. This novel combination therapy, termed chemoimmunotherapy, achieved near complete remission in mouse models of advanced prostate cancer.
A discovery has been made that may change the principles for treating certain types of cancer. The discovery relates to the so-called telomeres that constitute the ends of human chromosomes. Short telomeres are related to unhealthy lifestyles, old age and the male gender -- all of which are risk factors in terms of high mortality. Up until now, the assumption has been that short telomeres are related to ill health. The challenge for researchers worldwide has therefore been to find out whether or not the short telomeres were indeed a signifier or an indirect cause of increased mortality.
According to the American Cancer Society, in 2015 about 17,000 new cases of esophageal cancer will be diagnosed, and about 15,600 people will die from the disease. While the 5-year survival rate in the 1960s and 1970s was only about 5%, improvements in diagnosis, treatment, and management have led to improved survival. However, information is lacking about what happens to long-term survivors of esophageal cancer. New research shows that while five-year survival is up to 39%, these patients still face many health risks and should be monitored for 10 years or more.
After an update search, reviewers were able to include further studies in the assessment. The evidence base remained insufficient, however, and results of large studies remain unpublished.
Because depression in brain cancer patients is a common but often overlooked condition, oncologists should regularly screen tumor patients for depression, according to a new article. The authors also propose that more studies be completed to explore the efficacy of anti-depression treatments, as well as the value of depression biomarkers for future brain tumor research.
More than two-thirds (69 per cent) of bowel cancer patients say they weren’t advised to exercise regularly after their diagnosis – despite evidence that brisk physical activity is linked to better survival in bowel cancer, according to a study. The research is the largest study of its kind: more than 15,000 bowel cancer patients were asked about their current level of physical activity and whether they were advised to be more active after their diagnosis.
Long-term and frequent use of aspirin is associated with significantly decreased risk of cervical cancer, according to a study. According to the American Cancer Society, 12,900 new cases of cervical cancer will be diagnosed and 4,100 women will die from the disease in 2015.
A study tying the aging process to the deterioration of tightly packaged bundles of cellular DNA could lead to methods of preventing and treating age-related diseases such as cancer, diabetes and Alzheimer's disease, experts say.
German biologist Theodor Boveri observed early in the last century that cancer cells often harbor multiple copies of a subcellular structure that he had previously named the centrosome. He was also the first to suggest that the extra centrosomes drive cancer. Biologists have since learned a great deal about the structure and many functions of Boveri’s “special organ of cell division.” But why cancer cells harbor multiple copies of this organelle—and whether they are “addicted” to having so many—has remained unanswered. So has the question of whether healthy human cells even require centrosomes to divide. Now, 101 years after Boveri aired his suspicions, a paper may have some answers.
Taking aspirin reduces a person's risk of colorectal cancer, but the molecular mechanisms involved have remained unknown until a recent discovery. discovered that aspirin might exert its chemopreventive activity against colorectal cancer, at least partially, by normalizing the expression of epidermal growth factor receptor (EGFR) in gastrointestinal precancerous lesions. EGFR is overexpressed in about 80 percent of cases involving colorectal cancer, the third-leading cause of cancer-related death in the United States.
In recent years, research has shown that cancerous cells have a different metabolism -- essential chemical and nutritional changes needed for supporting the unlimited growth observed in cancer-- than normal cells. Now, scientists have identified a way that cells can reprogram their metabolism to overcome a tumor-suppressing mechanism known as senescence, solidifying the notion that altered metabolism is a hallmark of cancer progression.
DNA can be damaged by different environmental insults, such as ultraviolet light, ionizing radiation, oxidative stress or certain drugs. If the DNA is not repaired, cells may begin growing uncontrollably, leading to the development of cancer. Therefore, cells must maintain an intricate regulatory network to ensure that their DNA remains intact. Researchers have discovered a novel mechanism that controls a cell's response to DNA damage.
Soft tissue disorders like tumors are very difficult to recognize using normal X-ray machines, as there is hardly any distinction between healthy tissue and tumors. Researchers have now developed a technology using a compact synchrotron source that measures not only X-ray absorption, but also phase shifts and scattering. Tissue that is hardly recognizable using traditional X-ray machines is now visible.
Allergic reactions -- or at least the pre-existing inflammation from these reactions -- may set the stage for cancer to spread from one area to another, researchers have learned.
Clinical advice has been presented aimed at reducing overuse of cervical cancer screening in average risk women without symptoms. The advice suggests that physicians should start screening average risk women for cervical cancer at age 21 once every three years with cytology tests alone. Physicians may use a combination of cytology and HPV (human papillomavirus) testing once every five years in average risk women age 30 and older who prefer screening less often than every three years. Physicians should stop screening average risk women older than 65 years for cervical cancer who have had three consecutive negative cytology results or two consecutive negative cytology plus HPV test results within 10 years with the most recent test performed within five years.
Scientists have discovered that a certain class of receptors that inhibit immune response are crucial for the development of acute myeloid leukemia (AML), the most common acute leukemia affecting adults.
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