Latest news and research on all cancers and treatments, updated several times a week
A pilot scheme saw the consortium evaluate leading technologies for their ability to discover biomarkers that can detect cancer in its earliest stages, long before symptoms appear, when treatment is most likely to be effective. The technologies were tested against serum samples selected from a biobank of more than five million serum samples, collected from women as part of the UK Collaborative Trial for Ovarian Cancer Screening (UKCTOCS).
“..to begin a clinical trial of its cancer vaccine, which seeks to harness the immune system to stop growth of new blood vessels that feed tumors. The San Diego startup said Thursday that its therapy, ValloVax, will be tested in a Phase 1/2 trial against non-small cell lung cancer once the U.S. Food and Drug Administration approves the application. ValloVax targets proteins found in blood vessels induced by cancer that are not present in ordinary blood vessels. In mouse models, the vaccine inhibited tumor formation in melanoma, breast and lung cancer
“Antibody IgG2B is more effective at stimulating cancer immunity than previously known forms. Unlike other forms of antibody, IgG2B can work independently without needing help from other immune cells, making it more active and able to work in all tissues of thebody, meaning it could be a stronger immune stimulator than previous drugs.
“the initiation of the clinical trial investigating the combination immunotherapy of Amgen’s talimogene laherparepvec with Merck’s anti-PD-1 therapy, Keytruda (pembrolizumab), in patients with regionally or distantly metastatic melanoma. Talimogene laherparepvec is an investigational oncolytic immunotherapy which selectively replicates in tumors, but not in normal tissue to trigger an immune response against metastasized cancer cells
“demonstrating an overall response rate of 18.5% with KEYTRUDA, the company’s anti-PD-1 therapy, as assessed by RECIST v1.1, central review (n=5/27), in PD-L1 positive, advanced triple-negative breast cancer – one of the most aggressive forms of breast cancer. At the time of analysis, the median duration of response had not been reached with three of five responders on therapy for 11 months or more (range, 15 to 40+ weeks)
“The company has already developed a library of small molecules, known as kinases, that inhibit the family of enzymes that EGFR belongs to, and which are often implicated in cancer. Now their scientists are working backward, using growing genomic databases and sophisticated data-analysis software to spot the precise drivers of cancers that their compounds, or at least refined versions of them, may stop
Cancer News in Science Daily
“An imaging technology reveals that bacterial biofilms are associated with colon cancer, researchers report. The discovery draws on a novel way to "see" microbial community structure. Called combinatorial imaging, it could potentially be used to clinically diagnose pre-cancerous and cancerous conditions in the ascending colon.
“Scientists are closer to discovering a possible way to boost healthy cell production in cancer patients as they receive chemotherapy. By adding thymine -- a natural building block found in DNA -- into normal cells, they found it stimulated gene production and caused them to multiply.
“Targeted therapies are a growing and groundbreaking field in cancer care in which drugs or other substances are designed to interfere with genes or molecules that control the growth and survival of cancer cells. Now, scientists have identified a novel interaction between a microRNA and a gene that could lead to new therapies for the most common and deadly form of brain tumor, malignant glioma.
“Apheresis, the simple process of drawing blood, becomes a powerful therapeutic in extracorporeal photopherisis (ECP) according to clinicians and scientists. In the case of ECP, investigators' expanding knowledge of the basic science of immunology is on track to intersect with and inform the questions clinicians have about how best to use the power of ECP to treat patients.
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