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On a whim, he measured the rate of glutamine import into those cancer cells - and was stunned to find it was about 10 times higher than normal. That observation changed the course of his life's work. It also led to the identification of two specific amino acid transporters that are elevated in a wide spectrum of primary human cancers and aid tumor growth. For the past two decades, Bode has been working to develop highly targeted therapies to slow the uptake of glutamine and other nutrients that feed cancer.
Finally, increased risk for lung and bladder cancer was significantly associated with having a prior MI (RR 1.44 and 1.31, respectively). "Focus on ...
During the session "Principles of Immunotherapy" at the National Comprehensive Cancer Network 20th Annual Conference, Anthony J. Olszanksi, ...
Screening likely prompted by fear of malpractice, physician preference, poor record-keeping. Read more
Science Daily Cancer News
Researchers have learned how living beings can keep gene expression in check -- which might partly explain the uncontrolled gene expression found in many cancers. "Using yeast as a model organism, we studied the Tup1 protein, a negative regulator of gene expression," says a biologist, adding, "This protein binds to some genes and blocks their expression, helping to ensure genes that shouldn't be turned on remain inactive."
Fluorescent probes currently used for bioimaging (for example, cadmium selenide quantum dots) fluoresce brightly enough to show up on detectors but may be toxic and thus unsuitable for use in the body. Now scientists have found that tiny conjugated polyelectrolyte-nanoparticle probes produced by ultrasonication prove superior to commercial products.
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